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KMID : 0358319960370040385
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Korean Journal of Urology
1996 Volume.37 No. 4 p.385 ~ p.391
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Changes of Renal Function and Morphology in 3/4 Nephrectomized Rats
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Abstract
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To examine the effect renal mass reduction on compensatory renal hypertirophy and progressive glomerular sclerosis, 3/4 nephrectomy was performed in mature male rats. Serial changes in renal histology and function were investigated at weeks 1, 2,
6
and
12 after 3/4 nephrectomy. Mean glomerular diameter increased 29% during the first week thereafter the growth rate of glomeuli was similar to that of sham operated control's. Peak renal function was achieved at 6 weeks and thereafter progresively
decreased. The prominent glomerular sclerosis was found at 12th week. These results suggest that renal growth after renal mass reduction is a pathologic process ensuing progressive renal damage.
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